References

• For the most up to date references go to www.ncbi.nlm.nih.gov and check PubMed 

  then search keywords

  "methylselenocysteine" or "methylseleninic acid"

  for references to SeMCTM.

• For Reviews with references on Selenium and Cancer

  Bulletins of the STDA by Spallholz

  • May 2002 (Part 1) 

  • October 2002 (Part 2)

• Office of Dietary Supplements on Selenium

• Linus Pauling Institute on Selenium

• PDR Health Institute on Selenium

• World Health Organization on Selenium

Publications Relevant to Selenium at Pubmed

• Selenium and Colorectal Adenoma: Results of a Pooled Analysis. E.T. Jacobs, R. Jiang, D.S. Alberts et al. J. Natl. Cancer Inst, 
  17, 1669-1675, 2004.

• Delineation of the Molecular Basis for Selenium-Induced Growth Arrest in Human Prostate Cancer Cells by (Methylselenol) Oligonucleotide 
  Array. Y. Dong, H. Zhang, L.Hawthorn, H.E Ganther and C. Ip. Cancer Research, 63, 52-59, 2003.

• Se-Methylselenocysteine (SeMC). M. Rae. Advances in Orthomolecular Research, 2, 5-13, 2003.  (Review with 65 references) 

• Selenocompounds in Plants and Animals and Their Biological Significance. P. D. Whanger. Journal of The American College of Nutrition, 
  21,223-232, 2002. 

• Selenium-enriched Broccoli Decreases Intestinal Tumorigenesis in Multiple Intestinal Neoplasia in Mice. C.D. Davis,H. Zeng and J.W. Finley. 
  Journal of Nutrition 132,307-309, 2002.

• Allium Vegetables and the Risk of Prostate Cancer. A.D. Hsing, A.P. Chokkalingam et al. J. National Cancer Institute. 94, 1648-1651, 2002.

• Se-methylselenocysteine Induces Apoptosis through Capase Activation and Bax Cleavage Mediated by Calpin in SKOV-3 Ovarian Cancer Cells. 
  J.K. Yeo, et al. Cancer Letters, 182, 83-92, 2002.

• Intracellular Glutathione is a Cofactor in Methylseleninic Acid-Induced Apoptotic Cell Death of Human Hepatoma HEPG2 Cells. H.M. Shen and C.O. Ong. 
  Free Radical Biology and Medicine, 33, 552-561, 2002.

• New Concepts in Selenium Chemoprevention. C. Ip, Y. Dong and H.E. Ganther. Cancer Metastasis Reviews. 21, 281-289, 2002.

• Dimethyldiselenide and Methylseleninic Acid  Generate Superoxide in an In Vitro Chemiluminescence Assay: Implications for the Anticarcinogenic 
  Activity of L-Selenomethionine and L-Se-methlyselenocysteine. J.E. Spallholz, B.J. Shriver and T.W. Reid. Nutrition and Cancer  40, 31-34, 2001.

• Bioactivation of Chemopreventive Selenocysteine Se-conjugates and related Amino Acids by Amino Acid Oxidases Novel Route of Metabolism of 
  Selenoamino Acids. M. Rooseboom et al. Chemical Research and Toxicology, 14, 995-1005, 2001.

• Se-Methylselenocysteine; A New Compound for the Treatment of Breast Cancer. D. Medina, H. Thompson. H. Ganther and C. Ip. Nutrition and Cancer, 
  40,34-41, 2001.

• Se-Methylselenocysteine Induces Apoptosis Mediated by Reactive Oxygen Species in HL-60 Cells. U. Jung et al. Free Radical Biology and Medicine, 
  31,479-489, 2001.

• Selenium(Se) From High-Selenium Broccoli is Utilized Differently Than Selenite, Selenate and Selenomethionine, but is More Effective in Inhibiting 
  Colon Carcinogenesis. J.W. Finley and C.D. Davis. Biofactors. 14, 191-196, 2001.

• Preventing and Treating Cancer with Selenium in the New Millenium. J.E. Spallholz, B. Shriver, L.M. Boylan and T.R. Reid  Proceedings of the 
  Seventh Internation Symposium on Selenium in Biology and Medicine. Venice, Italy, 2000.

• Selenium From High-Selenium Broccoli Protects Rats from Colon Cancer. J.W.  Findley, C.D. Davis and Y. Feng. Journal of Nutrition 103, 2384-2389, 2000.

• In Vitro and In Vivo Studies of Methylseleninic Acid: Evidence That a Monomethylated Selenium Metabolite is Critical for Cancer Prevention.
  C. Ip, H.J. Thompon, Z. Zhu, and H.E. Ganther. Cancer Research, 60, 2882-2886, 2000.

• Chemical Speciation Influences Comparative Activity of Selenium-Enriched Garlic and Yeast in Mammary Cancer Prevention. C. Ip, M. Birringer, 
  E. Block, M. Kotrebai, J.F. Tyson, P.C. Uden and D.J. Lisk.  Journal of Agriculture and Food Chemistry, 5. 2000.

• Selenium Metabolism, Selenoproteins and Mechanisms of Cancer Prevention: Complexities with Thioredoxin Reductase. H.E.Ganther. 
  Cancinogenesis 20. 1657-1666, 1999

• Selenium-induced Inhibition of Angiogenesis in Mammary Cancer at Chemopreventive Levels of (Dietary) Intake. C. Jiang, W.Jiang, Ip,C., Ganther, H. 
  and Lu,I. Molecular Carcinogenesis. 26,213-225, 1999.

• The Retention and Distribution by Healthy Young men of Stable Isotopes of Selenium Consumed as Selenite, Selenate or Hydroponically Grown 
  Broccoli are Dependent on the Chemical Form. J. FINDLEY Journal of Nutrition 129,865-871,1999.

• Growing Alliums And Brassicas In Selenium- Enriched Soils Increases Their Anticarcinogenic Potential. Medical Hypothesis. 53, 232-235, 1999.

• Selenium from Broccoli is Metabolized Differently Than Se From Selenite, Selenate or Selenomethionine. J. Findley. Journal of Agricultural and 
  Food Chemistry. 46,3702-3707, 1998.

• Chemopreventive Agents: Selenium. G.F. Combes and W.P. Grey. Pharmacological Therapy 79, 179-192, 1998

• Lessons from Basic Research in Selenium and Cancer Prevention. C. Ip. Journal of Nutrition 128, 1845-1854, 1998.

• Should Selenium Enriched Vegetables be Consumed For the Prevention of Cancer? P.D. Whanger, J.L. Green and J.A. Butler.  Proceedings of the 
  Sixth International Symposium on the Uses of Selenium and Tellurium.  57-61, 1998. Scottsdale, AZ

• Novel Strategies in Selenium Cancer Chemoprevention Research. C. Ip and H.E. Ganther. In, Selenium in Biology and  Human Health, 
  R.F. Burk, Ed. Chapter 9, pp170-180. Springer-Verlag, Publisher  New York. 1998,

• Study of Prediagnostic Selenium Level in Toenails and the Risk of Advanced Prostate Cancer. K. Yoshizawa, W.C. Willet, S.L. Morris, 
  S.J. Stampfer, D. Spiegelman, E.B. Rimm and E. Giovannucci. Journal of the National Cancer Institute 90, 1219-1224, 1998.

• Chemical Transformations of Selenium in Living Organisms. Improved Forms of Selenium for Cancer Prevention.  H.E. Ganther and J.R. Lawrence. 
  Tetrahedron  53, 12299-12310,1997.

• Dietary Selenium: Time to Act-Low Bioavailability in Britain and  Europe Could be Contributing to Cancers, 
  Cardiovascular Disease and Subfertility. M.P. Rayman, British Medical Journal 314,387-388,1997.

• Speciation of Selenoamino acids and Organoselenium compounds in Selenium-enriched Yeast using High-performance Liquid 
  Chromatography-inductively Coupled Plasma Mass Spectrometry.  S.M. Bird, P.C. Uden, J.F. Tyson, E. Block and E. Denoyer. J. Analytical 
  Atomic Spectrophotometry. 12, 785-788, 1997.

• Effects of Selenium Supplementation for Cancer Prevention in Patients with Carcinoma of the Skin. L.C. Clark et al.  Journal of the American 
  Medical Association. 276, 1957-1963, 1996.

• Effect of an Aqueous Extract of Selenium-Enriched Garlic on in vitro and in vivo efficacy in Cancer Prevention. J. Lu, H. Pei, C. Ip, D.J. Lisk, 
  H. Ganther and H. J. Thompson. Carcinogenesis 17, 1903-1907, 1995.

• Efficacy of Cancer Prevention by High-Selenium Garlic is Primarily Dependent on the Action of Selenium. Carcinogenesis 16,2649-2652,1995

• Allium Chemistry: Identification of Selenoaminoacids in Ordinary and Selenium-enriched garlis, onion, and broccoli using Gas Chromatography 
  with Atomic Emission Detection. X.J. Cai, E. Block, P.C. Uden, Z. Zhang, B. D. Quimbly, and J.J. Sullivan. Journal of Agricultural Chemistry. 43, 
  1754-1757, 1995.

• Characterization of Tissue Profiles and Anicarcinogenic Responses in Rats Fed Natural Sources of Selenium-Enriched Products. C. Ip and J. Lisk.  
  Carcinogenesis. 15, 573. 1994.

• Enrichment of Selenium in Allium Vegetables for Cancer Prevention. C.P. Ip and D.J. Lisk. Carcinogenesis 15, 1881-1885, 1994.

• Enrichment of Selenium in Allium Vegetables for Cancer Prevention. Ibid. Carcinogenesis  9,1881-1885,1994a.

• Novel Strategies in Selenium Cancer Chemoprevention Research. Ip,C. and Ganther, H.E. in Selenium in Biology and Human Health R.F. Burk, Ed. 
  Chapter 9. Springer-Verlag, New York 171-180. 1994.

• Effect of Methylated Forms of Selenium on Cell Viability and the Induction of DNA Strand Breaks.  A.C. Wilson, H.J. Thompson, P.J. Schedin, 
  N.W. Gibson, and H.E. Ganther.  Biochemical Pharamacology 43, 1137-1141, 1992.

• Comparison of Selenium ans Sulfur Analogs in Cancer Prevention. C. Ip  and  H.E. Ganther. Carcinogenesis 13, 1167-1170, 1992.

• Mammary Cancer  Prevention  by Regular Garlic and Selenium-Enriched Garlic. C.Ip, D.J. Lisk and G.S. Stoewsand.  Nutrition and Cancer 17, 
  279-286, 1992.

• Chemical Form of Selenium, Critical Metabolites, and Cancer Prevention, C. Ip, C. Hayes. R.M. Budnick and H. Ganther. Cancer Research 51,595-600,1991.

• Activity of Methylated Forms of Selenium in Cancer Prevention. C. Ip and H.E. Ganther Cancer Research, 50, 1206-1211,1990.

• The Metabolism of Selenomethionine, Se-methylselenocysteine. their Selenonium Derivatives, and Trimethylselenonium in the Rat.  S. J. Foster, R.J. Kraus and H.E. Ganther. Archives of Biochemistry and Biophysics 251, 77-86, 1986b.

• Interaction of Vitamin C and Selenium Supplementation in the Modification of Mammary Carcinogenesis in the Rat. C. Ip Journal National Cancer 
  Institute 77, 299-303, 1986.

• Oxidation-Reduction Reactions of Organoselenium Compounds. I. Mechanism of Reaction between Seleninic Acids and Thiols. Journal of the American 
  Chemical Society. 100,5094-5102,1978.

• Biosynthesis of Se-methylselenocysteine and S-methylcysteine in Astragalus  Bisulcatus. D.M. Chen, S.N. Nigam and W.B. McConnell. 
  Canadian J. of Biochemistry  48,1278-1283, 1970.

Home